Bacterial redox protein azurin, tumor suppressor protein p53, and regression of cancer.

Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin.

The tumor suppressor protein p53 is known to induce either apoptosis or growth arrest depending on cellular background. We have previously reported that a bacterial redox protein azurin induces apoptosis in J774 cell line-derived macrophages whereas a site-directed mutant M44KM64E azurin shows very little cytotoxicity and fails to induce apoptosis in J774 cells. We now report that purified M44K...

Tumor Suppressor Protein p53 Complex Formation and Stabilization of the Apoptosis in J774 Macrophages through The Bacterial Redox Protein Azurin Induces

Immunohistochemical Evaluation of Human p53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ of the Breast

The focus of this study was to determine if early detection of mutant p53 accumulation may be an early indicator of tumor aggressiveness and transformation to invasive breast cancer. For this purpose, the p53 content of 100 human breast biopsies classified as ductal carcinoma (DCIS), was evaluated by immunohistochemical method. All specimens were microscopically classified into histologic types...

اثر هشت هفته تمرینات ترکیبی بر توان هوازی و سطح سرمی‌پروتئین سرکوب‌گر تومور P53 در بیماران مبتلا به سرطان پروستات: یک کارآزمایی بالینی

Background and Objectives: Physical activity plays a useful role in maintaining and improving the quality of life of men suffering from prostate cancer. The presence of tumor suppressor proteins including P53 is one of the regulatory mechanisms in controlling the progression of the disease. The purpose of this study was to investigate the effect of eight-week concurrent training on aerobic capa...

The Role of Tumor Protein 53 Mutations in Common Human Cancers and Targeting the Murine Double Minute 2–P53 Interaction for Cancer Therapy

The gene TP53 (also known as protein 53 or tumor protein 53), encoding transcription factor P53, is mutated or deleted in half of human cancers, demonstrating the crucial role of P53 in tumor suppression. There are reports of nearly 250 independent germ line TP53 mutations in over 100 publications. The P53 protein has the structure of a transcription factor and, is made up of several domains. T...